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Piperidolate/二苯哌酯
Piperidolate/二苯哌酯
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货号：A294526
同义名：
哌立度酯
Piperidolate是一种毒蕈碱受体拮抗剂，通过抑制乙酰胆碱在副神经节胆碱能受体位点的作用，主要用于研究肠道痉挛等相关症状。
Piperidolate/二苯哌酯 化学结构CAS号：82-98-4
Piperidolate/二苯哌酯 3D分子结构CAS号：82-98-4
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Piperidolate/二苯哌酯 纯度/质量文件 产品仅供科研
货号：A294526
标准纯度：
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批次纯度:
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NMR
HPLC
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Piperidolate/二苯哌酯 质控信息
AChR 亚型比较
产品名称
AChE
↓
↑
AChR
↓
↑
mAChR
↓
↑
nAChR
↓
↑
其他靶点
纯度
Donepezil
+++
hAChE, IC50: 11.6 nM
bAChE, IC50: 8.12 nM
98%
Loganin
++
AChE, IC50: 3.95 μM
99%+
topride HCl
++
AChE, IC50: 2.04 μM
98%
Dehydroevodiamine HCl
✔
99%+
Jatrorrhizine
++
AChE, IC50: 872 nM
99%+
Palmatine
++
AChE, IC50: 0.51 μM
95%
(-)-Huperzine A
++++
AChE (G4 form), Ki: 7 nM
98%
Galanthamine HBr
++
AChE, IC50: 0.35 μM
98%
Trospium chloride
✔
99%
Tiotropium Bromide Monohydrate
✔
97%
Gallamine Triethiodide
+
AChR, IC50: 68.0 μM
98%
Hexamethonium Bromide
✔
99%
Pancuronium dibromide
✔
98%
Neostigmine bromide
✔
98%
Orphenadrine citrate
✔
98%
Oxybutynin
✔
98%
Irsogladine
✔
PDE
99%
Pyridostigmine bromide
✔
99+%
Rivastigmine
+
AChR, IC50: 5.5 μM
98%
Paroxetine HCl
✔
99%
Rocuronium Bromide
✔
98%
Tropicamide
+++
M4 mAChR, IC50: 8 nM
98%
Diphenmanil methylsulfate
✔
97%
Umeclidinium bromide
✔
95%
Otilonium bromide
✔
98%
Flavoxate HCl
+
mAChR, IC50: 12.2 μM
99%
Ipratropium bromide
✔
98%
Diphenidol HCl
✔
98%
Darifenacin hydrobromide
++++
M3 mAChR, pKi: 8.9
98%
Aclidinium Bromide
++++
M2 mAChR, Ki: 0.1 nM
M4 mAChR, Ki: 0.21 nM
98%
Oxybutynin chloride
✔
99%
Pentoxyverine citrate
✔
98%
Solifenacin
✔
98%
Catharanthine
✔
98%
Benzethonium chloride
+++
α7 nAChRs, IC50: 122 nM
α4β2 nAChRs, IC50: 49 nM
99+%
Vinblastine sulfate
+
nAChR, IC50: 8.9 μM
99%
PNU-120596
++
α7 nAChR, EC50: 216 nM
99+%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Piperidolate/二苯哌酯 生物活性
描述
Piperidolate is an antimuscarinic, inhibits intestinal cramp induced by acetylcholine (rats and dogs) [3]. The mouse writhing test has been used to evaluate analgesic drugs. Atropine sulfate and eight of its substitutes have the protective effect of acetic acid-induced writhing in mice. Dicyclomine hydrochloride and orphenadrine hydrochloride produced an effect comparable with that of noramidopyrine, while atropine sulphate, oxyphenonium bromide and piperidolate hydrochloride were less potent[4].
Piperidolate/二苯哌酯 参考文献
[1]Hara M, Harberg FJ, Hudson LH. Antifibrillatory action of piperidolate hydrochloride (dactil) in hypothermia. AMA Arch Surg. 1957 Nov;75(5):780-4.
[2]PIPERIDOLATE hydrochloride. J Am Med Assoc. 1957 May 18;164(3):281.
[3]PIPERIDOLATE hydrochloride. J Am Med Assoc. 1957;164(3):281
[4]Kelkar MS. Atropine substitutes and the writhing syndrome in mice. Arch Int Pharmacodyn Ther. 1977;229(1):133‐137
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Piperidolate/二苯哌酯 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.09mL
0.62mL
0.31mL
15.46mL
3.09mL
1.55mL
30.92mL
6.18mL
3.09mL
Piperidolate/二苯哌酯 技术信息
CAS号82-98-4
分子式C21H25NO2
分子量
323.43
SMILES Code
O=C(OC1CN(CC)CCC1)C(C2=CC=CC=C2)C3=CC=CC=C3
MDL No.
MFCD00242588
别名
哌立度酯
运输蓝冰
InChI Key
KTHVBAZBLKXIHZ-UHFFFAOYSA-N
Pubchem ID
4839
存储条件
In solvent -20°C:3-6个月-80°C:12个月
溶解方案
细胞实验：
DMSO: 250 mg/mL(772.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
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Tags:
Piperidolate | 82-98-4 | mAChR | Muscarinic acetylcholine receptor | mAChR Inhibitor | GPCR/G Protein | Neuronal Signaling | mAChR | 仅供科研使用 | AmBeed-信号通路专用抑制剂
| Piperidolate/二苯哌酯 纯度/质量文件
| Piperidolate/二苯哌酯 亚型比较
| Piperidolate/二苯哌酯 生物活性
| Piperidolate/二苯哌酯 参考文献
| Piperidolate/二苯哌酯 实验方案
| Piperidolate/二苯哌酯 技术信息